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Thiamine is found naturally in many foods and is added to some fortified foods. You can get recommended amounts of thiamine by eating a variety of foods, including the following:

• Whole grains and fortified bread, cereal, pasta, and rice
• Meat (especially pork) and fish
• Legumes (such as black beans and soybeans), seeds, and nuts

Thiamine is found in multivitamin/mineral supplements, in B-complex dietary supplements, and in supplements containing only thiamine. Common forms of thiamine in dietary supplements are thiamine mononitrate and thiamine hydrochloride. Some supplements use a synthetic form of thiamine called benfotiamine.

Most people get enough thiamine from the foods they eat. Thiamine deficiency is rare in this country. However, certain groups of people are more likely than others to have trouble getting enough thiamine:

• People with alcohol dependence
• Older individuals
• People with HIV/AIDS
• People with diabetes
• People who have had bariatric surgery

Talk with your health care provider(s) about thiamine and other dietary supplements to help you determine which, if any, might be valuable for you.

You can develop thiamine deficiency if you don’t get enough thiamine in the foods you eat or if your body eliminates too much or absorbs too little thiamine.Thiamine deficiency can cause loss of weight and appetite, confusion, memory loss, muscle weakness, and heart problems. Severe thiamine deficiency leads to a disease called beriberi with the added symptoms of tingling and numbness in the feet and hands, loss of muscle, and poor reflexes. Beriberi is not common in developed countries.A more common example of thiamine deficiency is Wernicke-Korsakoff syndrome, which mostly affects people with alcoholism. It causes tingling and numbness in the hands and feet, severe memory loss, disorientation, and confusion.

Scientists are studying thiamine to better understand how it affects health. Here are some examples of what this research has shown.

Diabetes

People with diabetes often have low levels of thiamine in their blood. Scientists are studying whether thiamine supplements can improve blood sugar levels and glucose tolerance in people with type 2 diabetes. They are also studying whether benfotiamine (a synthetic form of thiamine) supplements can help with nerve damage caused by diabetes.

Heart failure

Many people with heart failure have low levels of thiamine. Scientists are studying whether thiamine supplements might help people with heart failure.

Alzheimer’s disease

Scientists are studying the possibility that thiamine deficiency could affect the dementia of Alzheimer’s disease. Whether thiamine supplements may help mental function in people with Alzheimer’s disease needs further study.

Thiamine has not been shown to cause any harm.

Yes. Some medicines can lower thiamine levels in the body. Here are a couple examples:

• Furosemide (Lasix), which is used to treat high blood pressure and swelling caused by excess fluid in the body
• Fluorouracil (5-fluorouracil and Adrucil), which is used in chemotherapy treatments for some types of cancer

Tell your doctor, pharmacist, and other health care providers about any dietary supplements and prescription or over-the-counter medicines you take. They can tell you if the dietary supplements might interact with your medicines or if the medicines might interfere with how your body absorbs, uses, or breaks down nutrients such as thiamine.